"Shake the Disease" is Depeche Mode's thirteenth UK single (released on 29 April 1985), and was one of two new songs released on the compilation The Singles (81-85) the same year, along with "It's Called a Heart". It reached number 18 in the UK singles chart. The American version of The Singles 81-85, Catching Up with Depeche Mode, also includes "Shake the Disease"'s B-side, "Flexible".

Band member Alan Wilder felt this song captured the essence of the band, stating "there's a certain edge to what we do that can make people think twice about things. If we've got a choice between calling a song "Understanding" or "Shake the Disease", we'll call it "Shake the Disease". There's a lot of perversity and innuendo in our lyrics, but nothing direct."

1985

Electronic / Synth-pop

Ladytron
Untitled

Peaches
Lovertits

The Glove
Like An Animal

Jaw
No Blue Peril

Susumu Hirasawa
Virtual Rabbit

Dillon Francis
This Mixtape Is Fire.

The Twins
Birds And Dogs / I'm Staying Alive

Pet Shop Boys
Paninaro (The Pet Shop Boys Mix)

Komëit
Falling Into Place

Centerfold
Play The Game

Denton And Cook
Hong Kong Beat & Other BBC TV Themes

Patterns (5)
Sunny Days